Organic Letters

ORGANIC LETTERS NaIO4-Mediated Selective Oxidative Halogenation of Alkenes and Aromatics Using understructure Metal Halides 2003 Vol. 5, No. 23 4501-4504 Gajanan K. Dewkar, Srinivasarao V. Narina, and Arumugam Sudalai* chemical Engineering and Process developing DiVision, National Chemical Laboratory, Pashan Road, Pune 411008, India sudalai@dalton.ncl.res.in bona fide September 21, 2003 ABSTRACT NaIO4 oxidizes alkali alloy halides efficiently in sedimentary medium to halogenate alkenes and aromatics and produce the corresponding halo derivatives in excellent regio and stereoselectivity. The musical comedy arrangement also demonstrates the unsymmetrical version of bromo hydroxylation using ?-cyclodextrin complexes, resulting in correspond ee. The 1,2-functionalization of olefins by the selective addition of two different functional groups, such as water or alcohols and halogens (halohydroxylation or haloalkoxylation), in a exceedingly regio- and enantioselective manner, mud great and challenging to original chemists.1 Such halo derivatives are wide used in the synthesis of pharmaceuticals, dyes, flame-retardants, additives and plasticizers, agrochemicals, and speciality chemicals.2 ceremonious halogenation methods3 typically use basal halogens, which are pollutants, and generate savage HX as byproducts.

Recently, the oxidative halogenation of olefins by metal halides has emerged as an important option for the synthesis of such * To whom parallelism should be addressed. Phone: +91-0205893300. telefax: + 91-20-5893359. (1) Tenaglia, A.; Pardigon, O.; Buono, G. J. Org. Chem. 1996, 61, 11291132. Haruyoshi, M.; Kiyoshi, T.; Masahiro, N.; Akira, H.; Yutaka, N.; Yasutaka, I. J. Org. Chem. 1994, 59, 5550-5555. Rodriguez, J.; Dulcere, j.-P. entailment 1993, 1177-1205. Block, E.; Schwan, A. L. In cosmopolitan Organic Synthesis; Trost, B. M., Fleming, I., Semmelhack, M. F., Eds.; Pergamon cheer: Oxford, 1991; Vol. 4, pp 344-347. (2) Ullmanns Encyclopedia Of industrial Chemistry, 6th ed.;...If you want to set a full essay, revise it on our website: Ordercustompaper.com

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